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Nitrooxyderivatives of cyclooxygenase-2 inhibitors
Document Type and Number: United States Patent 7776902

Abstract:
New compounds able to release COX-2 inhibitors and NO having formula (I):
M-T-YA—NO2 (I) for the treatment and/or prophylaxis of inflammatory processes.


Inventors: Del Soldato, Piero (Monza, IT) Santus, Giancarlo (Milan, IT)
Application Number: 10/516938
Publication Date: 08/17/2010


Filing Date: 06/20/2003
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Assignee: Nicox S.A. (Sophia Antipolis, FR)

The present invention relates to nitro-derivatives of cyclooxygenase-2 inhibitors (thereafter referred to as COX-2 inhibitors), pharmaceutical compositions containing them and their use for the treatment and/or prophylaxis of inflammations, such as for example arthritis, osteoarthritis, rheumatoid arthritis, dysmenorrhea, pain and fever, gastrointestinal and cardiovascular disorders, rheumatic diseases, neoplasia and Alzheimer's disease, for mitigating or removing the known side-effects of COX-2 inhibitors and for treating and/or preventing disorders resulting from elevated levels of cyclooxygenase-2.

Source : http://www.freepatentsonline.com/7776902.html

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