Synthesis Physicochemical Profile and PAMPA Study of New NO-Donor Edaravone Co-Drugs Original Research Article
Bioorganic & Medicinal Chemistry, In Press, Available online 8 December 2011
Barbara Rolando, Andrea Filieri, Konstantin Chegaev, Loretta Lazzarato, Marta Giorgis, Claudio De Nardi, Roberta Fruttero, Sophie Martel, Pierre-Alain Carrupt, Alberto Gasco
A new class of co-drugs obtained by joining antioxidant edaravone with a vasodilating substructure containing NO-donor functions, is presented. These compounds, characterized by a good gastrointestinal absorption, afford edaravone and the related NO-donor moieties when incubated in human serum and in rat liver homogenate. The title products are potentially useful for treating ROS-related conditions accompanied by decreased NO availability.