Je viens de trouver çà tout frais reçu sur Merck :
http://www.freepatentsonline.com/7622501.html
Title:
Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
Document Type and Number:
United States Patent 7622501
Abstract:
The invention encompasses novel compounds of Formula I,
which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula 1. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions
while also reducing the risk of thrombotic cardiovascular events. Voir le .pdf : http://www.freepatentsonline.com/7622501.pdf
et
http://www.freepatentsonline.com/7622502.html
Title:
Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
Document Type and Number:
United States Patent 7622502
Abstract:
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases.
The invention
also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions
while also reducing the risk of thrombotic cardiovascular events.
Voir le .pdf ici : http://www.freepatentsonline.com/7622502.pdf
... çà traite de NO et ... mais point de trace de NicOx...
Si quelqu'un peut nous éclairer, Merci d"avance.
Ils utilisent la techno de NicOx ou je me trompe ?