A Biochemical Way to Reduce Drug Side Effects?

Article trop long pour être C/C
Une alternative à la technologie de NicOx ?...

An emerging class of medicines works its magic by targeting unusual sites on biological molecules
By Melinda Wenner

Source :
http://www.scientificamerican.com/article.cfm?id=a-biochemical-way-to-reduce&sc=CAT_HLTH_20090813

Therapeutic agents known as allosteric ("other site") modulators take aim at targets outside of where classic drugs, and the body's own substances, normally hit selected molecules in the body.

• A new drug discovery approach focuses on a property known as allosterism.
  
• Allosteric drugs attach to biological molecules at binding sites distinct from those usually targeted
  by medications.
  
• Instead
  of activating or inhibiting the bound molecules, as classic drugs do,
  allosteric types can act more like dimmer switches and might, at times,
  cause fewer side effects.
  
• Such agents may be able to treat disorders that lack drug therapies today.
  

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