Exelixis and
Sanofi-aventis Sign Global License Agreement for XL147 & XL765 and Launch
Broad Collaboration for Discovery of PI3K Inhibitors Exelixis
to Receive $140 Million Upfront Payment and Guaranteed Research Funding
SOUTH SAN FRANCISCO,
Calif.--(BUSINESS WIRE)--Sanofi-aventis (PARIS:SAN) and (NYSE:SNY)
and Exelixis, Inc. (Nasdaq:EXEL) today announced a global license agreement for
XL147 and XL765 and a broad collaboration for the discovery of inhibitors of
phosphoinositide-3 kinase (PI3K) for the treatment of cancer. Activation of the
PI3K pathway is a frequent event in human tumors, promoting cell proliferation,
survival and resistance to chemotherapy and radiotherapy. Under the license,
sanofi-aventis will have a worldwide exclusive license to XL147 and XL765,
which are currently in phase 1 and phase 1b/2 clinical trials, and will have
sole responsibility for all subsequent clinical, regulatory, commercial and
manufacturing activities. Exelixis will participate in conducting ongoing and
potential future clinical trials and manufacturing activities.
Under the discovery collaboration,
Exelixis and sanofi-aventis will combine efforts in establishing several
pre-clinical PI3K programs and jointly share responsibility for research and
preclinical activities related to isoform-selective inhibitors of PI3K. Sanofi-aventis
will have sole responsibility for all subsequent clinical, regulatory,
commercial and manufacturing activities of any products arising from the
collaboration; however, Exelixis may be responsible for conducting certain
clinical trials.
Sanofi-aventis will pay Exelixis
aggregate upfront cash payments of $140 million under the license and
collaboration. Exelixis will also receive guaranteed research funding of $21
million over a three year research term under the collaboration. For the
license and the collaboration, Exelixis will be eligible to receive
development, regulatory and commercial milestones of over $1 billion in the
aggregate, as well as royalties on sales of any products commercialized under
the license or collaboration.
“Sanofi-aventis has a track
record of success in commercializing innovative cancer therapies and is deeply
committed to advancing the care of cancer patients,” said George A. Scangos,
Ph.D., president and chief executive officer of Exelixis. “We believe that
their expertise and resources will enable us to move aggressively in advancing
the development of XL147 and XL765 and other potential PI3K inhibitors. The
data generated to date in the XL147 and XL765 clinical programs suggest that
these compounds may have utility in treating diverse cancers. Sanofi-aventis
and Exelixis are committed to realizing the full potential of these compounds
and other PI3K inhibitors to provide cancer patients with new treatment
options.”
The effectiveness of the
license and collaboration is subject to antitrust clearance under the
Hart-Scott-Rodino Antitrust Improvements Act and other customary regulatory
approvals.
Oral Presentations Clinical data from the
phase 1 trials of XL147 and XL765 will be presented at the 2009 American
Society of Clinical Oncology Annual Meeting, which will be held from May 29 to
June 2, 2009 in Orlando, Florida:
- “Phase 1 dose-escalation study of XL147, a
PI3K inhibitor administered orally to patients with solid tumors” will be
presented on Monday, June 1, 2009, starting at 1:30 p.m. local time
(Abstract #3500)
- “A Phase 1 dose-escalation study of the
safety, pharmacokinetics (PK) and pharmacodynamics of XL765, a
PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with
advanced solid tumors” will be presented on Monday, June 1, 2009 starting
at 2:00 p.m. local time (Abstract #3502)
XL147 and XL765 target PI3K, which plays an
important role in cell proliferation and survival. XL765 also inhibits the
mammalian target of rapamycin (mTOR), which can be activated via upregulation
of PI3K, or via PI3K-independent mechanisms. mTOR is frequently activated in
human tumors and plays a central role in tumor cell proliferation
et cela continue, pour info, capi de 480 millions d'eur, ca vaut moins que Nicox. Vu les derniers upfronts touchés ca commence à devenir interessant.
A bon entendeur...
Jules