Research ArticleNCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA
International Journal of Hepatology
Volume 2011 (2011), Article ID 136816, 12 pages
our study demonstrates for the first time that a therapeutic treatment with NCX 1000 is effective in reducing steatosis, inflammation, oxidative stress, and insulin resistance in an in vivo rat model of diet-induced NASH. In this model, NCX 1000 does not appear to offer any advantage over equimolar amounts of the parent compound UDCA. However, the results of our study also support the use of combinations of lower doses of NCX 1000 with natural lipophilic antioxidants, such as vitamin E, as a valid option for the treatment of NASH. A clinical validation of this approach will remain mandatory. Conflict of InterestsDr. Jean Spénard is employed by Axcan Pharma Inc. that sponsored the study. He does not stand to gain personally from the publication of this paper.AcknowledgmentsThis work was supported by a partial Grant from Axcan Pharma
Inc. (Mont-Saint-Hilaire, QC, Canada) and from the Canadian Institutes of Health Research (CTP-79855). The authors thank Manlio Bolla of the NicOx Company for valuable comments.
c'est de la vieille molecule,abandonnée par nicox?
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