Nitrosated nonsteroidal antiinflammatory compounds

Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use

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Document Type and Number:
United States Patent 7883714

Abstract:
The
invention describes novel nitrosated nonsteroidal antiinflammatory
drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel
compositions comprising at least one nitrosated NSAID, and, optionally,
at least one compound that donates, transfers or releases nitric oxide,
stimulates endogenous synthesis of nitric oxide, elevates endogenous
levels of endothelium-derived relaxing factor or is a substrate for
nitric oxide synthase, and/or at least one therapeutic agent. The
invention also provides novel compositions comprising at least one
nitrosated NSAID, and at least one compound that donates, transfers or
releases nitric oxide, elevates endogenous levels of endothelium-derived
relaxing factor, stimulates endogenous synthesis of nitric oxide or is a
substrate for nitric oxide synthase and/or at least one therapeutic
agent. The invention also provides novel kits comprising at least one
nitrosated NSAID, and, optionally, at least one nitric oxide donor
and/or at least one therapeutic agent. The invention also provides
methods for treating inflammation, pain and fever; for treating
gastrointestinal disorders; for facilitating wound healing; for treating
and/or preventing gastrointestinal, renal and/or respiratory toxicities
resulting from the use of nonsteroidal antiinflammatory compounds; for
treating inflammatory disease states and/or disorders; and for treating
and/or preventing ophthalmic diseases and/or disorders.

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Assignee:
NicOx S.A. (FR)

Application Number:
12/636306

Publication Date:
02/08/2011