(WO/2010/014516) NITRO DERIVATIVES OF FURASEMIDE AND THEIR USE AS DIURETICS
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Pub. No.: WO/2010/014516 International Application No.: PCT/US2009/051788
Publication Date: 04.02.2010 International Filing Date: 27.07.2009
IPC: C07D 491/04 (2006.01), A61K 31/4355 (2006.01), A61P 9/00 (2006.01), C07D 519/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) (All Except US).
NICOX S.A. [FR/FR]; Taissounieres HB4 1681 Route Des Dolines, BP 313 Sophia Antipolis F-06560 Valbonne (FR) (All Except US).
ALI, Amjad [GB/US]; (US) (US Only).
SEBHAT, Iyassu, K. [GB/US]; (US) (US Only).
FRANKLIN, Christopher, L. [US/US]; (US) (US Only).
RUPPRECHT, Kathleen, M. [US/US]; (US) (US Only).
BAKER, Robert, K. [US/US]; (US) (US Only).
NARGUND, Ravi, P. [US/US]; (US) (US Only).
YAN, Lin [US/US]; (US) (US Only).
HUO, Pei [US/US]; (US) (US Only).
SHEN, Dong-Ming [US/US]; (US) (US Only).
ALMIRANTE, Nicoletta [IT/IT]; (IT) (US Only).
BIONDI, Stefano [IT/IT]; (IT) (US Only).
FERRARIO, Massimiliano [IT/IT]; (IT) (US Only).
NICOTRA, Alessia [IT/IT]; (IT) (US Only).
Inventors: ALI, Amjad; (US).
SEBHAT, Iyassu, K.; (US).
FRANKLIN, Christopher, L.; (US).
RUPPRECHT, Kathleen, M.; (US).
BAKER, Robert, K.; (US).
NARGUND, Ravi, P.; (US).
YAN, Lin; (US).
HUO, Pei; (US).
SHEN, Dong-Ming; (US).
ALMIRANTE, Nicoletta; (IT).
BIONDI, Stefano; (IT).
FERRARIO, Massimiliano; (IT).
NICOTRA, Alessia; (IT).
Common
Representative: MERCK SHARP & DOHME CORP.; Richard S. Parr 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) .
Priority Data:
61/137,250 29.07.2008 US
61/189,034 15.08.2008 US
Title: NITRO DERIVATIVES OF FURASEMIDE AND THEIR USE AS DIURETICS
Abstract: A compound having the structure wherein X is selected from the group consisting of: a bond, -NHCH2(CH2)nCH2OC(O), -CH2NHC(O)CH2NHC(O)-, -CH2OC(O), -OCH(CH3)OC(O)-, -OCH2OC(O)-, -O-, -NR1-, -CR1R3-, -(CH2)P-, -(CH2)qNR1C(O)-, -CHR5NR2C(O)-, -(CH2)qC(O)-, -(CH2)qC(O)NR1-, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
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WO/2010/012567) GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY
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Pub. No.: WO/2010/012567 International Application No.: PCT/EP2009/058572
Publication Date: 04.02.2010 International Filing Date: 07.07.2009
IPC: C07J 41/00 (2006.01), A61K 31/573 (2006.01), A61P 27/02 (2006.01), A61P 5/44 (2006.01), C07J 71/00 (2006.01)
Applicants: NICOX S.A. [FR/FR]; Taissounières HB4 - 1681 route des Dolines - BP313 F-06560 Sophia Antipolis -Valbonne (FR) (All Except US).
BENEDINI, Francesca [IT/IT]; (IT) (US Only).
BONFANTI, Annalisa [IT/IT]; (IT) (US Only).
CHIROLI, Valerio [IT/IT]; (IT) (US Only).
STEELE, Rebecca [GB/IT]; (IT) (US Only).
ONGINI, Ennio [IT/IT]; (IT) (US Only).
BIONDI, Stefano [IT/IT]; (IT) (US Only).
Inventors: BENEDINI, Francesca; (IT).
BONFANTI, Annalisa; (IT).
CHIROLI, Valerio; (IT).
STEELE, Rebecca; (IT).
ONGINI, Ennio; (IT).
BIONDI, Stefano; (IT).
Agent: BARCHIELLI, Giovanna; (IT) .
Priority Data:
61/085,294 31.07.2008 US
61/122,896 16.12.2008 US
Title: GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY
Abstract: The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
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