AMicale des COXiens

Forum des actionnaires particuliers de NicOx
AccueilAccueil  GalerieGalerie  S'enregistrerS'enregistrer  ConnexionConnexion  

Partagez | 

 new NO-donor aspirins

Aller en bas 

MessageSujet: new NO-donor aspirins   Mer 12 Aoû - 7:44

A series of (nitrooxyacyloxy)methyl esters of aspirin were synthesized and evaluated as new NO-donor aspirins. Different amounts of aspirin were released in serum from these products according to the nature of nitrooxyacyloxy moiety present. In the aromatic series, there is a rather good linear correlation between the amount of aspirin released and the potencies of the products in inhibiting platelet aggregation induced by collagen. Both the native compounds and the related nitrooxy-substituted acid metabolites were able to relax rat aorta strips precontracted with phenylephrine, in keeping with a NO-induced activation of the sGC as a mechanism that underlies the vasodilator effect. The products here described are new improved examples of NO-donor aspirins containing nitrooxy groups. They could represent an alternative to the use of aspirin in a variety of clinical applications.
Revenir en haut Aller en bas
luky luké


Nombre de messages : 248
Age : 68
Localisation : Nouveau résident à Panama
Date d'inscription : 29/05/2008

MessageSujet: Re: new NO-donor aspirins   Mer 12 Aoû - 13:56

Signé :
Nicox Research Institute, Via Ariosto 21, 20091, Bresso (Milano), Italy
J. Med. Chem., Article ASAP
Publication Date (Web): August 4, 2009
Copyright © 2009 American Chemical Society

Merci Simis de cette information
Revenir en haut Aller en bas
Voir le profil de l'utilisateur
new NO-donor aspirins
Revenir en haut 
Page 1 sur 1

Permission de ce forum:Vous ne pouvez pas répondre aux sujets dans ce forum
AMicale des COXiens :: Forum public :: Echanges sur NicOx-
Sauter vers: